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Between 15 and 20 weeks’ gestation, the mother may be given the option to have a screening test for Down syndrome and open neural tube defects, such as spina bifida. Included in the screening panel are tests for alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG), unconjugated estriol, and sometimes inhibin A—a marker that turns the triple test into a quad test. This blood screening panel provides an opportunity to assess the risk of these conditions occurring without performing the more invasive amniocentesis procedure.